Testosterone Enanthate is slowly absorbed from the lipid phase of testosterone Enanthate in the injected fat into the muscle; Testosterone Enanthate can therefore be administered at intervals of two to four weeks. Testosterone in plasma is 98 percent dependent on a specific testosterone-estradiol-binding globulin and is about two percent free. In general, this amount of SHBG in plasma will determine the distribution of free and bound forms of testosterone and determine the half-life of free testosterone concentration. About 90 percent of the testosterone dose is excreted in urine as testosterone glucuronic and sulfuric acid conjugates and metabolites; About 6% of a dose is excreted in feces, mostly in unconjugated form. Inactivation of testosterone takes place primarily in the liver. Testosterone is metabolized to various 17-keto steroids in two different ways. There are significant changes in the half-life of testosterone reported in the literature, ranging from 10 to 100 minutes. Women with inoperable metastatic (skeletal) breast cancer who progressed one to five years before the postmenopausal period. The primary purpose in the treatment of these women is the ablation of the ovaries. Women taking these are the risks of developing breast cancer.